SrasV1, Main, Exploration, bibRecord, 003C52

The spleen as a target in severe acute respiratory syndrome.

Identifieur interne : 003C52 ( Main/Exploration ); précédent : 003C51; suivant : 003C53

The spleen as a target in severe acute respiratory syndrome.

Auteurs : Jun Zhan [République populaire de Chine] ; Ruishu Deng ; Junmin Tang ; Bo Zhang ; Yan Tang ; Jeffrey K. Wang ; Feng Li ; Virginia M. Anderson ; Michael A. Mcnutt ; Jiang Gu

Source :

FASEB journal : official publication of the Federation of American Societies for Experimental Biology [ 1530-6860 ] ; 2006.

RBID : pubmed:17077309

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Amorces ADN, Antigènes CD (analyse), Autopsie, Coronavirus (génétique), Coronavirus (isolement et purification), Génome viral, Humains, Hybridation in situ, Mâle, Rate (anatomopathologie), Réaction de polymérisation en chaîne, Syndrome respiratoire aigu sévère (anatomopathologie), Séquence nucléotidique.
MESH :
- analyse : Antigènes CD.
- anatomopathologie : Rate, Syndrome respiratoire aigu sévère.
- génétique : Coronavirus.
- isolement et purification : Coronavirus.
- Adulte, Adulte d'âge moyen, Amorces ADN, Autopsie, Génome viral, Humains, Hybridation in situ, Mâle, Réaction de polymérisation en chaîne, Séquence nucléotidique.

English descriptors

KwdEn :
- Adult, Antigens, CD (analysis), Autopsy, Base Sequence, Coronavirus (genetics), Coronavirus (isolation & purification), DNA Primers, Genome, Viral, Humans, In Situ Hybridization, Male, Middle Aged, Polymerase Chain Reaction, Severe Acute Respiratory Syndrome (pathology), Spleen (pathology).
MESH :
- chemical , analysis : Antigens, CD.
- genetics : Coronavirus.
- isolation & purification : Coronavirus.
- pathology : Severe Acute Respiratory Syndrome, Spleen.
- Adult, Autopsy, Base Sequence, DNA Primers, Genome, Viral, Humans, In Situ Hybridization, Male, Middle Aged, Polymerase Chain Reaction.

Abstract

It has been proposed that immune injury is the central mechanism of pathogenesis of the infectious disease, severe acute respiratory syndrome (SARS). To gain a better understanding of immune injury in the spleen, we investigated the number and distribution of various immune cell types in the spleens of SARS patients. We performed autopsies on six confirmed SARS cases, with six normal subjects as controls; spleen samples from these autopsies were examined with hematoxylin and eosin (H&E) sections, in situ hybridization for SARS virus genomic sequences, and immunohistochemistry with seven monoclonal antibodies to five cell types. The number and distribution of these cells were measured and analyzed using an image analysis system. SARS genomic sequences were detected in all SARS spleens. The SARS spleens all had severe damage to the white pulp and showed an alteration of the normal distribution of various cell types. Immunocytes in the red pulp were decreased by 68.0-90.7% except for CD68+ macrophages and human leukocyte antigen (HLA)-DR positive antigen-presenting cells (APC), which were decreased to a lesser degree. On average, CD68+ macrophages were increased in size by 2.21-fold. We hypothesize that the collapse of the splenic immune system plays a key role in the clinical outcome of these patients.

DOI: 10.1096/fj.06-6324com
PubMed: 17077309

Affiliations:

Le document en format XML

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<term>Coronavirus (isolation & purification)</term>
<term>DNA Primers</term>
<term>Genome, Viral</term>
<term>Humans</term>
<term>In Situ Hybridization</term>
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<term>Polymerase Chain Reaction</term>
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<term>Autopsie</term>
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<front><div type="abstract" xml:lang="en">It has been proposed that immune injury is the central mechanism of pathogenesis of the infectious disease, severe acute respiratory syndrome (SARS). To gain a better understanding of immune injury in the spleen, we investigated the number and distribution of various immune cell types in the spleens of SARS patients. We performed autopsies on six confirmed SARS cases, with six normal subjects as controls; spleen samples from these autopsies were examined with hematoxylin and eosin (H&E) sections, in situ hybridization for SARS virus genomic sequences, and immunohistochemistry with seven monoclonal antibodies to five cell types. The number and distribution of these cells were measured and analyzed using an image analysis system. SARS genomic sequences were detected in all SARS spleens. The SARS spleens all had severe damage to the white pulp and showed an alteration of the normal distribution of various cell types. Immunocytes in the red pulp were decreased by 68.0-90.7% except for CD68+ macrophages and human leukocyte antigen (HLA)-DR positive antigen-presenting cells (APC), which were decreased to a lesser degree. On average, CD68+ macrophages were increased in size by 2.21-fold. We hypothesize that the collapse of the splenic immune system plays a key role in the clinical outcome of these patients.</div>
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Serveur d'exploration SRAS

The spleen as a target in severe acute respiratory syndrome.

The spleen as a target in severe acute respiratory syndrome.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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